Introducing, PCDx

The most sophisticated & comprehensive next-generation cancer diagnostic test available today.
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Accurate.

Paradigm’s 5000x average depth of coverage ensures confidence in that both positive and negative calls are correct. This type of assurance cannot be achieved at lower levels.

Advanced.

Through next-generation sequencing, PCDx assesses the most clinically-actionable genomic variations in cancer, including: mutations, gene fusions, mRNA expression, and copy number variations.

Fast.

Paradigm promises a clinically relevant turnaround time. Customers can expect 4 to 5 business days from sample receipt to reporting ensures continuity of clinical care.

Comprehensive test results, in record time.

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Copy Number Variations

CNVs are alterations of the DNA of the cancer genome that result in the cell having abnormal copies of one or more sections of the DNA. These alterations can have a significant impact on response to therapy (e.g., HER2).

mRNA Expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional protein. NGS-based mRNA analysis enables the significant multiplexing of biomarker targets (e.g., ER, ERCC1).

Rearrangements & Gene Fusions

Somatic rearrangements usually result in the formation of a fusion gene, derived from two disrupted normal genes, from which a fusion transcript and protein is generated (e.g., EML4-ALK).

DNA Mutations

Changes in the DNA sequence of chromosomes, including insertions, deletions and base substitutions. Somatic mutation analysis has become standard of practice for solid tumors in order to identify therapeutic sensitizing and resistance mutations (e.g., EGFR, KRAS, BRAF).

Results in 4-5 days.

PCDx promises a clinically relevant turnaround time of 4 to 5 business days from sample receipt to reporting.
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Day 1

Sample is received and pathology confirms initial diagnosis with H&E.

Day 2

Tumor DNA & RNA are extracted, purified and quantified.

Day 3

DNA & RNA library creation.

Day 4

Next-generation sequencing.

Day 5

Clinical interpretation of results, quality assurance performed and clinical report delivered.

How to order PCDx

Receive your PCDx test results in 3 simple steps. Follow the instructions below to start the process.
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1

Fill out the requisition form

The PDF test requisition form can be completed digitally, within Adobe Acrobat.

Download the form

2

Send us the form via fax/email

For your convenience, the requisition form can be sent to Paradigm via email or fax.

View ordering information

3

Mail the tissue sample

Please follow our preparation & shipping guidelines to ensure quality DNA/RNA analysis.

View tissue prep guidelines

Receive your results.

Results will identify all actionable classes of genomic alterations in cancer-related genes.

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